Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 315, Issue 1-2, Pages 167-169Publisher
ELSEVIER
DOI: 10.1016/j.jns.2011.11.022
Keywords
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS); Kawasaki disease; Corpus callosum; Diffusion-weighted image; Delirium; Cardiac aneurysm
Categories
Funding
- Ministry of Health, Labor and Welfare of Japan [H23-Nanchi-Ippan-78, H22-Nanchi-Ippan-132, 21B-5]
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We reported four patients (2 to 10 years) with Kawasaki disease complicated by clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). All were treated with gamma-globulin (2 to 6 g/kg) after the diagnosis of Kawasaki disease, the fever being alleviated between day 6 and 25. One of two patients exhibiting a poor response to gamma-globulin had a cardiac aneurysm as a sequela. Their neurological manifestations (delirious behavior and drowsiness), laboratorial hyponatremia, and radiological abnormalities completely disappeared. It is important for pediatricians to acknowledge that MERS can be observed in patients with Kawasaki disease, especially in older children, and that they might be at high risk for cardiac abnormalities. (C) 2011 Elsevier B.V. All rights reserved.
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