Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 319, Issue 1-2, Pages 130-132Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2012.04.004
Keywords
Creutzfeldt-Jakob disease (CJD); Diffusion-weighted imaging (DWI); Apparent diffusion coefficient (ADC)
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Familial Creutzfeldt-Jakob disease (CJD) with V180I shows different clinical characteristics from classical CJD and is difficult to diagnose in the early stage. We report a CJD180 patient in whom results of diffusion-weighted imaging (DWI) led us to suspect CJD before symptoms started. A 68-year-old woman presented to our hospital with headache and nausea and underwent magnetic resonance imaging. DWI showed cortical hyperintensity. Three months later, cognitive function started to decline and CJD180 was diagnosed following genetic examination. In the early stage, ADC values were not decreased and single positron emission computed tomography demonstrated a decreased pattern like Alzheimer disease. (C) 2012 Elsevier B.V. All rights reserved.
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