Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 312, Issue 1-2, Pages 191-193Publisher
ELSEVIER
DOI: 10.1016/j.jns.2011.08.014
Keywords
Dopamine dysregulation syndrome; Deep brain stimulation; Subthalamic nucleus; Impulse control disorders
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Funding
- Fundacion de Investigacion Biomedica del Hospital Gregorio Maranon (Madrid, Spain)
- Programa de Intensificacion de la Actividad Investigadora en el Sistema Nacional de Salud [I3SNS]
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Dopamine dysregulation syndrome is a complication of the dopaminergic treatment for Parkinson's disease, probably related to sensitization of the mesolimbic dopamine system. The relationship between dopamine dysregulation syndrome and deep brain stimulation of the subthalamic nucleus remains unclear. We report three patients with Parkinson's disease who developed de novo dopamine dysregulation syndrome after deep brain stimulation of the subthalamic nucleus. We hypothesized that the combined effect of dopaminergic replacement therapy and deep brain stimulation on the limbic territory of the subthalamic nucleus could have precipitated the dopamine dysregulation syndrome in these patients, by inducing hyperstimulation of the mesolimbic dopamine system. The outcome of postoperative dopamine dysregulation syndrome is poor despite deep brain stimulation adjustments, attempts to reduce the dose of dopaminergic drugs and the addition of quetiapine or antidepressants. (C) 2011 Elsevier B.V. All rights reserved.
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