Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 302, Issue 1-2, Pages 89-95Publisher
ELSEVIER
DOI: 10.1016/j.jns.2010.11.012
Keywords
Alzheimer's disease; White matter; Diffusion tensor imaging; Voxel-based morphometry
Categories
Funding
- Ministry for Health, Welfare & Family Affairs, Republic of Korea [A050079]
- Catholic Medical Center Research Foundation
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Regional atrophy of gray matter (GM) in Alzheimer's disease (AD) is well known; however, the relationship between macroscopic and microscopic changes of cerebral white matter (WM) is uncertain. The aim of this study was to investigate the pattern of GM, WM atrophy, and microscopic WM changes in the same individuals with AD. All subjects (10 AD and 15 healthy controls [HC]) underwent a MRI scanning at 1.51. including a 3-dimensional volumetric scan and diffusion tensor imaging (DTI). We performed statistical parametric mapping (SPM) with DTI to evaluate the patterns of the microscopic WM changes, as well as voxel-based morphometry (VBM) for GM and WM volume changes between patients with AD and HC. GM atrophy was detected, mainly in posterior regions, and WM atrophy was similarly distributed, but less involved on VBM analysis. Unlike WM atrophy on VBM analysis, microscopic WM changes were shown in the medial frontal, orbitofrontal, splenium of the corpus callosum, and cingulum on DTI analysis with SPM. We demonstrated that the pattern of macroscopic WM atrophy was similar to GM atrophy, while microscopic WM changes had a different pattern and distribution. Our findings suggest that WM atrophy may preferentially reflect the secondary changes of GM atrophy, while microscopic WM changes start earlier in frontal areas before GM and WM atrophy can be detected macroscopically. (C) 2010 Elsevier B.V. All rights reserved.
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