Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 289, Issue 1-2, Pages 128-134Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2009.08.028
Keywords
Magnetoencephalography; Parkinson's disease; Alzheimer's disease; Functional connectivity; Synchronization; Oscillations; Resting state; Graph analysis; Small-world networks
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The pathophysiological mechanisms underlying clinical symptoms in neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD) are incompletely understood Magnetoencephalography (MEG) is a relatively new functional neuroimaging technique, which allows the simultaneous recording of the brain's magnetic activity from large arrays of sensors covering the whole head. MEG studies in PD and AD have identified characteristic patterns of abnormal oscillatory activity in different frequency bands. Furthermore, MEG studies aimed at the characterization of distributed functional networks have demonstrated distinct patterns of abnormal connectivity in demented and non-demented PD. as well as in AD. In PD abnormal oscillatory activity and disturbed connectivity may respond differently to dopaminergic treatment. Further studies in this field could benefit from new technological developments such as ultra low field MRI and from the application of a well-defined theoretical framework such as graph theory to the study of disturbed brain networks. (C) 2009 Elsevier B V. All rights reserved
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