Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 298, Issue 1-2, Pages 35-41Publisher
ELSEVIER
DOI: 10.1016/j.jns.2010.09.001
Keywords
Idiopathic normal pressure hydrocephalus; Cerebral blood flow; Preclinical stage; Single photon emission computed tomography; Autoradiography method; Region of interest; Multiple comparison
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Funding
- Research Committee of Normal Pressure Hydrocephalus and Related Disorders, Studies on the Etiology, Pathogenesis and Therapy
- Ministry of Health, Labor and Welfare of Japan [Dementia-General-003]
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In patients with idiopathic normal pressure hydrocephalus (iNPH), ventriculomegaly and narrowed subarachnoid spaces at the high convexity appear in magnetic resonance (MR) images before the occurrence of objective symptoms. In addition, quantitative regional cerebral blood flow (rCBF) has been reported to be reduced in iNPH patients with objective symptoms. To determine whether reduced rCBF is responsible for the appearance of symptoms, we compared rCBF in patients with suspected iNPH with no objective triad symptoms (NOS), iNPH patients with apparent objective triad symptoms (AOS) and normal control subjects (NC). Regional CBF was quantified in 35 Regions-of-interest (ROIs) by 123I-IMP single photon emission computed tomography (SPECT) using the autoradiography (ARC) method. Multiple comparisons showed that, in all brain regions examined except for in the frontal white matter, rCBF in the NOS group was significantly lower than that in the NC group, but in all brain regions, not significantly different from that of the AOS group. These results suggest that factors other than rCBF in the resting state are responsible for the occurrence of objective symptoms of iNPH. (C) 2010 Elsevier B.V. All rights reserved.
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