Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 280, Issue 1-2, Pages 120-122Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2009.02.357
Keywords
Myasthenia gravis treatment; Rituximab; Monoclonal antibody; Muscle-specific tyrosine kinase
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In generalized myasthenia gravis (MG), a wide array of immunosuppressive and immunomodulating treatments is being used in clinical practice, but most drugs lack evidence from randomized controlled trials supporting their use. Furthermore, many patients develop serious side effects or do not respond sufficiently to these drugs. We report three patients with generalized MG who were treated with rituximab, a monoclonal antibody against CD20+ cells that causes prolonged B cell depletion. In all three patients, treatment with rituximab led to a Sustained clinical improvement and discontinuation or reduction of prednisolone and other drugs. Rituximab was well tolerated. Therapy with rituximab was guided by the total count of peripheral B lymphocytes. Reviewing the anecdotal literature on rituximab for MG, we conclude that preliminary data on the efficacy and safety of rituximab are encouraging and that further studies in MG seem warranted. (C) 2009 Elsevier B.V. All rights reserved
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