Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 287, Issue 1-2, Pages 143-146Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2009.08.007
Keywords
Parkinson's disease; Repetitive transcranial magnetic stimulation; Supplementary motor area
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Funding
- Ministry of Health, Labour and Welfare of Japan [17231401]
- Japan Society for the Promotion of Science for Young Scientists
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A double-blind sham-controlled study demonstrated that high-frequency repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) provided relief of motor symptoms in patients with Parkinson's disease (PD). However, it remains to be determined which parkinsonian symptoms were improved by this treatment. Subanalysis of Unified Parkinson Disease Rating Scale revealed that rTMS over SMA significantly improved bradykinesia in PD. Results support the hypothesis that neuronal activity of SMA was profoundly associated with hypokinetic symptoms in PD. (C) 2009 Elsevier B.V. All rights reserved.
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