Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 271, Issue 1-2, Pages 186-190Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2008.04.019
Keywords
cerebellar ataxia; autoantibodies; gamma-aminobutyric acid (GABA); glutamic acid decarboxylase (GAD); synaptic transmission; forskolin
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Anti-glutamic acid decarboxylase autoantibodies (GAD-Abs) are found in some patients with cerebellar ataxia. We reported previously that CSF IgGs depress cerebellar GABAergic synaptic transmissions by a presynaptic mechanism. Using whole-cell recordings from rat cerebellar slices, we found in the present study that CSF IgG-induced depressive effects were abolished by absorption of GAD-Abs using recombinant GAD. Furthermore, forskolin, an activator of cAMP, recovered the CSF IgG-induced reduction of GABA release. Our results provide evidence that GAD-Abs in the CSF elicited physiopathological effects on cerebellar GABA synapses in vitro and that such synaptic impairment was reversible. (C) 2008 Elsevier B.V. All rights reserved.
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