Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 266, Issue 1-2, Pages 9-12Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2007.08.027
Keywords
Lewy bodies; casein kinase II; alpha-synuclein; phosphorylation; Parkinson's disease
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Funding
- National Research Foundation of Korea [핵06B3110] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We reported previously that phosphorylation by cascin kinase II (CKII) regulates the interaction between alpha-synuclein and its binding partner synphilin-1, and that both CKII alpha and beta subunits co-localize with alpha-synuclein in cytoplasmic inclusions in transfected cells. In this study, we extended these observations to the brains of patients with Parkinson's disease (PD) and examined whether CKII subunits are present in Lewy bodies. Immumohistochemical studies on PD brains harboring Lewy bodies revealed a positive stain for CKII beta but not for CKII alpha. In addition, CKII beta subunits co-localized with alpha-synuclein in most Lewy bodies. These findings suggest that CKII beta subunits may play a role in the formation of intracytoplasmic inclusions in human alpha-synucleinopathies either through phosphorylation events or through a separate mechanism linked to the beta subunit itself (c) 2007 Elsevier B.V. All rights reserved.
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