Journal
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
Volume 106, Issue 5, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/jnci/dju068
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Funding
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- European Research Council [ERC-2009-AdG 232997]
- Cancer Research UK [14136, 16491] Funding Source: researchfish
- Medical Research Council [MC_UU_12015/1, G1000143, G0401527, MC_U106179471] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10135, NF-SI-0512-10114] Funding Source: researchfish
- MRC [MC_UU_12015/1] Funding Source: UKRI
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337 327) heterogeneous cohort of women, with 10 062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER+PR+ disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER-PR- disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.
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