Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 88, Issue -, Pages 488-496Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2018.08.049
Keywords
Selective laser melting; Porous scaffold; Pore structure; Bone ingrowth; Osteointegration
Funding
- National Science Foundation of China [11872135]
- Medical Scientific Research Foundation of Health and Family Planning Commission of Chongqing [2017XMSB00012079, 2017MSXML073]
- Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education
- Medical Scientific Nurture Research of the Stomatological Hospital of Chongqing Medical University [PYM201605]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2015shmszx0108]
- key projects of Chongqing Yubei District Science and Technology Commission [2015(01)]
- Chongqing Science and Technology Commission General Social Livelihood Project [cstc2015shmszx1008]
- Innovation Team Building at Institutions of Higher Education in Chongqing in 2016
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A properly designed porous scaffold can accelerate the osseointegration process, and the use of computer-aided design (CAD) and additive manufacturing (AM) techniques has the potential to improve the traditional porous scaffold approach. In this study, we evaluate the effect of porous Ti6Al4V (Ti) with different pore structures on osteointegration and osteogenesis. Porous Ti scaffolds with different pore structures based on four commercially available implants were designed and manufactured by CAD and selective laser melting (SLM). Micro-CT showed that SLM was able to produce Ti scaffolds with different pore structures. The mechanical properties evaluated by finite element analysis and compression tests indicated that the four porous scaffolds in our study were mechanically adapted, despite their different mechanical properties. Then, we used 3D-printed porous discs to culture human bone marrow mesenchymal stem cells (hBMMSCs), the main seed cells of bone tissue engineering. The results showed no significant difference among the four groups in cell morphology, viability and proliferation. In addition, four groups showed a comparable mineralization ability even though Ti-g had a higher alkaline phosphatase activity (ALP). In vivo tests in a rabbit model showed that all four groups were suitable for new bone ingrowth and integration. These findings indicate that the four different pore structures in the Ti scaffolds provided good osteointegration and osteogenesis.
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