Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 5, Issue 1, Pages 62-70Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2011.08.004
Keywords
Cartilage; Osteoarthritis; Second harmonic generation; Collagen; Spring-mass model; Disease simulation; Articular surface; Irreversible degradation
Funding
- Arthritis Research UK
- NIHR Biomedical Research Unit into Musculoskeletal Disease
- Nuffield Orthopaedic Centre
- University of Oxford
- Canada Foundation for Innovation
- Canadian Institute for Photonic Innovations
- Natural Sciences and Engineering Research Council of Canada
- Ministere du Developpement economique, Innovation et Exportation
- Fonds Quebecois de la Recherche sur la Nature et les Technologies
- Versus Arthritis
- Cancer Research UK [18887] Funding Source: researchfish
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With increasing interest in treating osteoarthritis at its earliest stages, it has become important to understand the mechanisms by which the disease progresses across a joint. Here, second harmonic generation (SHG) microscopy, coupled with a two-dimensional spring-mass network model, was used to image and investigate the collagen meshwork architecture at the cartilage surface surrounding osteoarthritic lesions. We found that minor weakening of the collagen meshwork leads to the bundling of fibrils at the surface under normal loading. This bundling appears to be an irreversible step in the degradation process, as the stress concentrations drive the progression of damage, forming larger bundles and cracks that eventually form lesions. (C) 2011 Elsevier Ltd. All rights reserved.
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