Journal
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
Volume 52, Issue 5, Pages 486-492Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
DOI: 10.3839/jksabc.2009.083
Keywords
antioxidant; gamma-irradiation; Rhodiola rosea; rhodiosin; UWLA
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Funding
- Korean government (NTEST) [2007-00614]
- Rural Development Administration
- KRJBB Research Initiative Program, Republic of Korea
- National Research Foundation of Korea [2007-00614] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Rural Development Administration (RDA), Republic of Korea [PJ00710320091136300] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The EtOAc fraction of Rhodiola rosea ethanolic extracts showed a strong antioxidant activity. Through activity-guided fractionation and purification, we isolated two flavonol glycosides, which were identified as the well known flavonoids, rhodionin (1) and rhodiosin (2). To compare their antioxidant activities, we used an authentic aglycone compound, herbacetin (3). Among the compounds tested, rhodiosin (2) exhibited strong antioxidant activity, with IC50 values of 0.21 and 0.15 mu M against center dot OH and center dot O-2(-), respectively. Rhodiosin (2) (100 mg/kg) reduced MDA content in the liver induced by irradiation when given prior to exposure of gamma-radiation.
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