Journal
POLYMER TESTING
Volume 42, Issue -, Pages 26-36Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymertesting.2014.12.010
Keywords
Carboxymethylchitosan; Hydrogel; Thermo-responsive; pH-responsive; Controlled release
Funding
- National Research Council of Thailand (NRCT) [R2557B065]
- Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education
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Carboxymethylchitosan (CMC) hydrogels containing thermo-responsive poly(N-isopropylacrylamide) (poly(NIPAAm)) and pH-responsive poly(acrylic acid) (poly(AA)) were prepared via a free radical polymerization in the presence of hexamethylene-1,6-di-(aminocarboxysulfonate) crosslinking agents. A proper ratio of CMC to NIPAAm and AA used in the reaction was investigated such that the thermo- and pH-responsive properties of the hydrogels were obtained. Water swelling of the hydrogels was improved when the solution pH was in basic conditions (pH 10) or the temperature was below its lower critical solution temperature (LCST). Effects of the change in solution temperature and pH on water swelling properties of the hydrogel as well as the releasing rate of an entrapped drug were also investigated. The hydrogels were not toxic and showed antibacterial activity against Straphylococcus aureus (S. aureus). The pH- and thermo-responsive properties of this novel smart hydrogel might be efficiently used as dual triggering mechanisms in controlled drug release applications. (C) 2015 Elsevier Ltd. All rights reserved.
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