Journal
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
Volume 10, Issue 1, Pages 93-105Publisher
SPRINGER
DOI: 10.1007/s13738-012-0129-9
Keywords
Sulfamethoxazole; Molecularly imprinted sensors; Taguchi method; Foods; Plasma
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Funding
- post-graduate office of Guilan University
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A new man-tailored biomimetic sensor for sulfamethoxazole host-guest interactions and potentiometric transduction is presented. The host cavity was shaped on a polymeric surface assembled with methacrylic acid monomers by radical polymerization. Molecularly imprinted particles (MIP) were mixed with graphite powder, paraffin oil and ionic site. Using the Taguchi method, this study analyzed the optimum conditions for preparing the carbon paste electrode. The controllable factors used in this study consisted the weights of (1) MIP, (2) paraffin oil, (3) graphite, and (4) the ionic site. The percentage contribution of each controllable factor was also determined. MIP-modified electrode exhibited a Nernstian response (57.2 mVdecade(-1)) in a wide concentration range of 6.0 x 10(-8) to 3.1 x 10(-3) mol L-1 with a lower detection limit of 3.5 x 10(-9) mol L-1. The sensor was successfully applied to the determination of sulfamethoxazole concentrations in foods and plasma.
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