Journal
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
Volume 20, Issue 6, Pages 588-598Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617714000241
Keywords
Neuropsychological assessment; Memory; Executive Function; Attention; Cognitive assessment; Cognitive screener
Categories
Funding
- Blueprint for Neuroscience Research, National Institutes of Health [HHS-N-260-2006-00007-C]
- NIH [P30MH062512, P50DA026306, P01DA012065, R01MH060720, R01MH073433, R01MH058076, R01MH078748, R01MH078737, U01MH083506, R01MH083552, R01MH081861]
- Institute for Rehabilitation and Research
- Frazier Rehabilitation Institute/Jewish Hospital
- Craig Hospital
- Casa Colina Centers for Rehabilitation
- National Institute on Aging
- California Department of Public Health California Alzheimer's Disease Centers program
- Ken and Ruth Davee Foundation
- NIDRR [H133A080035, H133G090022, H133A980023, H133B090024]
- DoD [W81XWH-0802-0159]
- NINDS [U01 NS 056 975 02]
- NHLBI K23 [K23HL085766 NIA, 1RC2AG036498-01]
- OppNet [N01-AG-6-0007]
- National Institute of Health [H133B090024, N01-AG-6-0007, H133N060022, H133G070138, B6237R, U01AR057929, R01HD054659, R01DC008552, P30AG013854, R01 NS058302, R01HD061400, F31-DA035708, T32-DA31098, 1U5AR057943-01, HHSN260200600007, 1U01DK082342-01, AG-260-06-01, HD05469]
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This study describes psychometric properties of the NIH Toolbox Cognition Battery (NIHTB-CB) Composite Scores in an adult sample. The NIHTB-CB was designed for use in epidemiologic studies and clinical trials for ages 3 to 85. A total of 268 self-described healthy adults were recruited at four university-based sites, using stratified sampling guidelines to target demographic variability for age (20-85 years), gender, education, and ethnicity. The NIHTB-CB contains seven computer-based instruments assessing five cognitive sub-domains: Language, Executive Function, Episodic Memory, Processing Speed, and Working Memory. Participants completed the NIHTB-CB, corresponding gold standard validation measures selected to tap the same cognitive abilities, and sociodemographic questionnaires. Three Composite Scores were derived for both the NIHTB-CB and gold standard batteries: Crystallized Cognition Composite, Fluid Cognition Composite, and Total Cognition Composite scores. NIHTB Composite Scores showed acceptable internal consistency (Cronbach's alphas = 0.84 Crystallized, 0.83 Fluid, 0.77 Total), excellent test-retest reliability (r: 0.86-0.92), strong convergent (r: 0.78-0.90) and discriminant (r: 0.19-0.39) validities versus gold standard composites, and expected age effects (r = 0.18 crystallized, r = -0.68 fluid, r = -0.26 total). Significant relationships with self-reported prior school difficulties and current health status, employment, and presence of a disability provided evidence of external validity. The NIH Toolbox Cognition Battery Composite Scores have excellent reliability and validity, suggesting they can be used effectively in epidemiologic and clinical studies.
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