Journal
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
Volume 15, Issue 3, Pages 372-382Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617709090523
Keywords
Magnetic resonance imaging; Neuropsychology; Frontal lobe; Parietal lobe; Temporal lobe; Dementia
Categories
Funding
- Alzheimer's Association [NIRG-05-13067]
- NIH-NIA [AG 19142, AG 16574, AG06786, AG 11378]
- Clarice Smith and Abigail Van Buren Alzheimer's Disease Research Program
- Mayo Foundation, USA
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Functional magnetic resonance imaging (fMRI) shows changes in multiple regions in amnestic mild cognitive impairment (aMCI). The concept of MCI recently evolved to include nonamnestic syndromes, so little is known about fMRI changes in these individuals. This study investigated activation during Visual complex scene encoding and recognition in 29 cognitively normal (CN) elderly, 19 individuals with aMCI, and 12 individuals with nonamnestic MCI (naMCI). During encoding, CN activated in extensive network that included bilateral occipital-parietal-temporal cortex; precuneus; posterior cingulate: thalamus; insula; and medial, anterior, and lateral frontal re.-ions. Amnestic MCI activated an anatomic subset of these regions. Non-amnestic MCI activated an even smaller anatomic subset. During recognition, CN activated the same regions observed during encoding except the precuneus. Both MCI groups again activated a Subset of the regions activated by CN. During encoding, CN had greater activation than aMCI and naMCI in bilateral temporoparietal and frontal regions. During recognition, CN had greater activation than aMCI in predominantly temporoparietal regions bilaterally, while CN had greater activation than naMCI in larger areas involving bilateral temporoparietal and frontal regions. The diminished parietal and frontal activation ill naMCI may reflect compromised ability to perform nonmemory (i.e., attention/executive, visuospatial function) components of the task. (JINS, 2009, 15, 372-382.)
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