Journal
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
Volume 16, Issue 1, Pages 6-16Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617709990750
Keywords
Standard scores; Immunologic disease; Neuropsychology; Normalization; psychometrics; Brain
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The Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) is a consensus neuropsychological battery with established reliability and validity. One of the difficulties in implementing the MACFIMS ill clinical settings is the reliance on manualized norms front disparate sources. In this study. we derived regression-based norms for the MACFIMS, using a unique data set to control for standard demographic variables (i.e., age, age(2), sex, education). Multiple sclerosis (MS) patients (n = 395) and healthy Volunteers (n = 100) did not differ in age. level of education, sex, or race. Multiple regression analyses were conducted oil the performance of the healthy adults, and the resulting models were used to predict MS performance on the MACFIMS battery. This regression-based approach identified higher rates of impairment than manualized norms for many of the MACFIMS measures. These findings suggest that there are advantages to developing new norms front a single sample using the regression-based approach. We Conclude that the regression-based norms presented here provide a valid alternative to identifying cognitive impairment as measured by the MACFIMS. (JINS, 2010, 16, 6-16.)
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