Journal
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
Volume 15, Issue 6, Pages 898-905Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617709990816
Keywords
Mild cognitive impairment; Cerebral small vessel disease; Alzheimer's disease; Cognitive profile; Vascular dementia; Leukoaraiosis
Categories
Funding
- National Natural Science Key Foundation of China [30830045]
- National Key Technology R&D Program in the Eleventh Five-year Plan Period [2006BAI021301]
- National Basic Research 973 [2006CB500700]
- Beijing Natural Science Foundation [7071004]
- Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality
Ask authors/readers for more resources
Controversy surrounds the differences of the cognitive profile between mild cognitive impairment resulting from cerebral small vessel disease (MCI-SVD) and mild cognitive impairment associated with prodromal Alzheimer's disease (MCI-AD). The aim Of this Study was to explore and compare the cognitive features of MCI-SVD and MCI-AD. MCI-SVD patients (n=56), MCI-AD patients (n=30), and normal control subjects (n=80) were comprehensively evaluated with neuropsychological tests covering five cognitive domains. The performance was compared between groups. Tests that discriminated between MCI-SVD and MCI-AD were identified. Multiple cognitive domains were impaired in MCI-SVD group, while memory and executive function were mainly impaired in MCI-AD group. Compared with MCI-SVD, MCI-AD patients performed relatively worse on memory tasks, but better on processing speed measures. The AVLT Long Delay Free Recall. Digit Symbol Test, and Stroop Test Part A (performance time) in combination categorized 91.1% of MCI-SVD patients and 86.7% of MCI-AD patients correctly. Current study suggested a nonspecific neuropsychological profile for MCI-SVD and a more specific cognitive pattern in MCI-AD. MCI-AD patients demonstrated greater memory impairment with relatively preserved mental processing speed compared with MCI-SVD patients. Tests tapping these two domains might be potentially useful for differentiating MCI-SVD and MCI-AD patients. (JINS, 2009 15, 898-905.)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available