Journal
POLYMER DEGRADATION AND STABILITY
Volume 112, Issue -, Pages 10-19Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2014.12.008
Keywords
Cross-linked PCL implants; Enzymatic degradation; Thermomyces lanuginosus lipase; Degradation rate
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Funding
- National Science Foundation of China (NSFC) [51133004, 81361140343]
- National Basic Research Program of China (National 973 program) [2011CB606206]
- Sino-German Center for Research Promotion [GZ 756, GZ 905]
- European Commission Research and Innovation [PIRSES-GA-2011-295218]
- Science and Technology Department of Sichuan Province [2013FZ0003]
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The cross-linked poly(e-caprolactone) (PCL) implants were directly prepared via the ring-opening polymerization of CL with cross-linker (BTB). The in vitro enzymatic degradation of the resulting implants was performed with Thermomyces lanuginosus lipase. We saw that the cross-linked PCL implants degraded in lipase via the surface erosion mechanism. The higher the molar ratio of monomers to catalyst or the higher the cross-linker amount in feeding dose, the slower the degradation rate of the cross-linked PCL implants. Moreover, the degradation rate of the cross-linked PCL implants was lower than that of the uncross-linked ones, which could markedly reduce the acidic degradation products. The macroscopic observation results indicated that the cross-linked PCL implants had good form-stability. The changes in thermal properties showed that the degradation occurred in both amorphous and crystalline regions. The results implied that the highly cross-linked PCL implants had great potential as controlled drug release agents. (C) 2014 Elsevier Ltd. All rights reserved.
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