Journal
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
Volume 109, Issue 10, Pages 688-693Publisher
ELSEVIER TAIWAN
DOI: 10.1016/S0929-6646(10)60112-X
Keywords
adult T cell leukemia; aneuploidy; HTLV; p53; spindle assembly checkpoint
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Funding
- National Institute of Allergy and Infectious Diseases
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Human T-cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia, was the first human retrovirus to be isolated It is now the 30(th) anniversary of the initial discovery of HTLV-1 This review discusses recent insights into the role of the HTLV-1 Tax oncoprotein in cellular proliferation and the abrogation of cellular checkpoints that lead to disease progression
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