Journal
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
Volume 32, Issue 11, Pages 2777-2783Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jeurceramsoc.2012.02.058
Keywords
Sol-gel glass; Copper; Nano-particles; Bioactive glasses; Functionalization
Categories
Funding
- Italian Ministry MIUR [2006032335]
Ask authors/readers for more resources
Bioactive sol gel glasses, based on the ternary system 15CaO center dot 5P(2)O(5)center dot 80SiO(2), doped with Cu were synthesized and characterized in order to define the oxidation state of Cu as a function of thermal treatments. In particular, we were able to optimize the condition to obtain: (i) the reduction of Cu2+ to Cu-0 followed by nano-aggregation of metal nano-particles (MeNPs) into glass matrix; (ii) a mixed Cu2+/Cu+/Cu-0 NPs-containing glasses; (iii) a Cu2+-containing glasses. Successively, the surface of sol-gel glasses was functionalized by means of organic molecules (amino and mercapto alcohols) to give rise to a system that can interact with the functional groups of the drugs. The functionalization was carried out as a function of the sol-gel glass composition, organic molecules concentration and temperature of the process; the results indicate a preference for the amino groups. The bioactivity (formation of an apatitic layer after simulated body fluid SBF test) was verified for the functionalized sol-gel Cu2+-containing glasses and they are still bioactive. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available