Journal
POLYMER CHEMISTRY
Volume 6, Issue 23, Pages 4206-4209Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5py00466g
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Funding
- National Natural Science Foundation of China [21374066, 21074078]
- Suzhou Science and Technology Program for Industrial Application Foundation [SYG201429]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Soochow-Waterloo University Joint Project for Nanotechnology from Suzhou Industrial Park
- Innovative Graduate Research Program of Jiangsu Province [CXZZ12_0810]
- CelluForce
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Poly(ethyl ethylene phosphate) (PEEP) modified cellulose nano-crystals (CNCs) (CNC-g-PEEP) were synthesized through a grafting onto process, in which a combination of ring-opening polymerization (ROP) and Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry was utilized. The resulting suspension of negatively-charged CNC-g-PEEP nanocrystals could be used to encapsulate doxorubicin (DOX) by electrostatic interactions and release the drug in the tumor cell environment.
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