Treatment of bullous pemphigoid with low- dose oral cyclophosphamide: a case series of 20 patients

BackgroundCyclophosphamide has been commonly used for the treatment of pemphigus vulgaris and mucous membrane pemphigoid with satisfactory results. Published data of this therapeutic approach for bullous pemphigoid are scant and showed significant morbidity and mortality. ObjectiveTo assess the clinical efficacy and safety of low-dose oral cyclophosphamide (CFM) (50-100mg/day) in patients with refractory bullous pemphigoid. MethodsWe conducted a retrospective study including patients with bullous pemphigoid treated with CFM in the department of Dermatology in the Hospital Clinic of Barcelona, Spain. ResultsComplete response was observed in 11 (58%) over 19 evaluable patients. Cyclophosphamide at 50mg/day was enough to achieve clinical remission in eight of these patients. Partial response was observed in four (21%) more patients. Bone marrow suppression appeared in 12 (60%) patients, but treatment discontinuation was only required in three (15%) cases. Gastrointestinal intolerance occurred in one (5%) patient. One patient died during therapy from heart failure (not attributed to CFM) and another patient developed acute myeloid leukaemia 1.5years after CFM therapy. ConclusionsIn our series, CFM had a marked therapeutic effect in bullous pemphigoid. These results of efficacy are similar to those described in other autoimmune blistering skin diseases. Only a few patients had to discontinue their treatment due to adverse effects. Therefore, we consider that low-dose oral CFM can be valuable therapeutic alternative in elderly patients with moderate-to-severe bullous pemphigoid.