Journal
POLYMER CHEMISTRY
Volume 6, Issue 40, Pages 7097-7099Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5py01204j
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Funding
- National Natural Science Foundation of China [21274121, 51173163]
- National Basic Research Program of China [2011CB606001]
- Fundamental Research Funds for the Central Universities [2015QNA4036]
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We reported a facile method to prepare camptothecin (CPT) loaded ultrathin hydrogel films based on a polymeric prodrug via layer by layer (LbL) thiol-ene click chemistry. Free camptothecin could be sustainedly released from the ultrathin hydrogel film within 24 hours through the hydrolysis of ester bonds between the hydrogel backbone and the camptothecin moieties.
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