4.7 Article

Reactive oxygen species (ROS)-responsive tellurium-containing hyperbranched polymer

Journal

POLYMER CHEMISTRY
Volume 6, Issue 15, Pages 2817-2821

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5py00050e

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Funding

  1. National Basic Research Program of China [2013CB834502]
  2. National Science Foundation [21425416]
  3. Foundation for Innovative Research Groups of the National Natural Science Foundation of China [21421064]

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Materials responsive to reactive oxygen species (ROS) at a physiological level are of great significance in diagnostic and therapeutic applications. We have synthesized a water-soluble tellurium-containing hyperbranched polymer and demonstrated that it forms a kind of ROS-responsive aggregate. In aqueous environment, the polymer aggregates can swell under biologically relevant concentration of H2O2, which could be expected to find applications in fields such as elimination of excess ROS.

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