Journal
POLYMER CHEMISTRY
Volume 6, Issue 16, Pages 3155-3163Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5py00196j
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Funding
- National Science Foundation for Distinguished Young Scholars [50925310]
- National Science Foundation of China [21174087, 21474079]
- Major Project of Chinese National Programs for Fundamental Research and Development (973 Project) [2009CB930400]
- Program for New Century Excellent Talents in University [NCET-13-0453]
- China Postdoctoral Science Foundation [18420011, 2014T70909]
- Fundamental Funds for the Central Universities [08142027, 08143101]
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Highly cross-linked and monodispersed polyphosphazene nanoparticles (NPs) exhibiting strong fluorescence were prepared by a remarkably simple one-pot polycondensation of hexachlorocyclotriphosphazene (HCCP) and 4,5-dibromofluorescein (DBF). The morphology and size of the resulting poly (cyclotriphosphazene-co-dibromofluorescein) (PCTPDBF) NPs can be facilely tuned by varying the solvent and reactant concentration. The fluorescent DBF units were isolated and fastened in the cross-linked structures, which can well suppress the concentration-quenching effect of small fluorescent probes. Hence, the PCTPDBF NPs can emit bright yellow fluorescence at any concentration. The PCTPDBF NPs could enter HeLa and H9C2 cells and were located in the cytoplasm. Combined with their excellent biocompatibility and improved resistance to photobleaching and protein interference, they can be used as ideal fluorescent agents for cell imaging.
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