Journal
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
Volume 165, Issue 13, Pages B559-B564Publisher
ELECTROCHEMICAL SOC INC
DOI: 10.1149/2.1001811jes
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Funding
- Iran National Science Foundation (INSF) [95835873]
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The amplified voltammetric sensor, a novel approach was used for the determination of two anticancer drugs (doxorubicin and 5-fluorouracil). The novel sensor was fabricated by surface amplification of carbon paste electrode (CPE) with 1-ethyl-3-methylimidazolium tetrafluoroborate (EMITFB) and CuO decorated on single wall carbon nanotubes (CuO-SWCNTs). The EMITFB/CuO-SWCNTs/CPE creates a dramatic improvement in oxidation reaction of doxorubicin in aqueous solution. The main advantages of EMITFB/CuO-SWCNTs/CPE compared with a simple sensor are an increase of about x 3.5 in current and a decrease of about 60 mV in the oxidation potential of doxorubicin. Doxorubicin and 5-fluorouracil can be oxidized at potentials of approximately 680 and 970 mV on EMITFB/CuO-SWCNTs/CPE surface that may be sufficient for the simultaneous determination of drugs in a mixture. Doxorubicin and 5-fluorouracil were observed at detection limits of 6.0 nM and 0.4 mu M, respectively, on EMITFB/CuO-SWCNTs/CPE surface. EMITFB/CuO-SWCNTs/CPE was efficiently used in the detection of doxorubicin in injection and serum samples. (C) 2018 The Electrochemical Society.
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