Journal
POLYMER BULLETIN
Volume 73, Issue 5, Pages 1321-1342Publisher
SPRINGER
DOI: 10.1007/s00289-015-1550-x
Keywords
Stimuli-sensitive polymers; Graft copolymerization; Sodium alginate; Poly(N-isopropylacrylamide); Poly(acrylic acid)
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Funding
- Kirikkale University [2011/07]
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The significant developments in the field of polymer have advanced the synthesis of polymer-based materials and have expanded their use in a wide variety of applications. Today, polymers can be designed to change their properties in response to a single stimulus or multiple stimuli. Such types of polymers are called stimuli-sensitive or stimuli-responsive polymers, and have been utilized for controlled release in the field of biomedicine. Herein, we report the use of alginate (SA) based graft copolymer with poly(N-isopropylacrylamide) (PIPAAm) and poly(acrylic acid) (PAA) to synthesize dual stimuli-sensitive beads via microwave-assisted graft copolymerization method for controlled release of indomethacin (IND). It is demonstrated that the polymer beads composed of SA-g-PIPAAm/PAA are sensitive to pH and temperature. The structure of successfully prepared stimuli-sensitive beads by cross-linking via glutaraldehyde is characterized by FTIR, X-RD and SEM analysis.
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