Journal
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
Volume 56, Issue 3, Pages 455-458Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jccs.200900068
Keywords
2-Aminothiazoles; Poly(ethylene glycol); Ambient temperature
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Funding
- National Council Science of Republic of China
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A simple and practical procedure for the synthesis of 2-aminothiazoles from alpha-tosyloxyketones and thioureas is described using PEG-400 [poly(ethylene glycol-400)] at ambient conditions. The developed protocol is successfully applied for the preparation of an anti-inflammatory drug, Fanetizole.
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