Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 21, Issue 10, Pages 1807-1813Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532010001000003
Keywords
Piper; antifungal; analogs; amides
Categories
Funding
- FAPESP
- CNPq
- CAPES
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The antifungal leaves extract from Piper scutifolium was submitted to bioactivity-guided chromatographic separation against Cladosporium cladosporioides and C. sphaerospermum yielding piperine, piperlonguminine and corcovadine as the active principles which displayed a detection limit of 1 mu g. Structure-activity relationships were investigated with the preparation of twelve analogs having differences in the number of unsaturations, aromatic ring substituents and in the amide moiety. Analogs having a single double-bond and no substituent in the aromatic ring displayed higher activity, while N,N,-diethyl analogs displayed higher dose-dependent activity.
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