Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 20, Issue 1, Pages 195-U243Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532009000100029
Keywords
biotransformation; 2,5-diaryltetrahydrofuran; endophytic fungus; (-)-grandisin; trypanocidal activity
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [04/07935-6]
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The biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity (IC50 9.8 mu mol L-1) similar to the natural precursor (IC50 3.7 mu mol L-1).
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