Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 19, Issue 7, Pages 1298-1305Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532008000700011
Keywords
PHBV; double emulsion/solvent evaporation technique; hydrophilic model drug; microparticles
Categories
Funding
- CNPq (Brazil)
- Fundacao Araucaria (Brazil)
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Poly(3-hydroxybutirate-co-3-hydroxyvalerate) (PHBV) microparticles containing a water-soluble model drug, metformin hydrochloride (MH), were obtained by a double emulsion/solvent evaporation technique. Several formulations were prepared in order to investigate the influence of each composition on the encapsulation efficiency (EE). The highest value of EE (9.76%) was obtained using simultaneously pH alkalinization and NaCl addition in the external water phase of the formulation. SEM study revealed a spherical morphology and a rough surface. The crystalline diffraction intensities for the MH-loaded microparticles were lower than that verified for the physical mixture. FTIR results suggested that no chemical bond between the polymer and the drug was formed. Also thermal analyses indicated a favorable interaction between MH and PHBV. In vitro drug release demonstrated the influence of the PHBV on the dissolution profile of MH.
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