Journal
POLYMER
Volume 77, Issue -, Pages 102-112Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2015.09.037
Keywords
Collagen; Wet spinning; Fibres; Biopolymer; Collagen crosslinking; Carbonated hydroxyapatite; Bone
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Funding
- EPSRC Centre for Innovative Manufacture in Medical Devices (MeDe Innovation)
- Clothworkers' Centre for Textile Materials Innovation for Healthcare
- EPSRC [EP/J017620/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J017620/1] Funding Source: researchfish
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One of the limitations of electrospun collagen as bone-like fibrous structure is the potential collagen triple helix denaturation in the fibre state and the corresponding inadequate wet stability even after crosslinking. Here, we have demonstrated the feasibility of accomplishing wet-stable fibres by wet spinning and diacid-based crosslinking of collagen triple helices, whereby fibre ability to act as bone-mimicking mineralisation system has also been explored. Circular dichroism (CD) demonstrated nearly complete triple helix retention in resulting wet-spun fibres, and the corresponding chemically crosslinked fibres successfully preserved their fibrous morphology following 1-week incubation in phosphate buffer solution (PBS). The presented novel diacid-based crosslinking route imparted superior tensile modulus and strength to the resulting fibres indicating that covalent functionalization of distant collagen molecules is unlikely to be accomplished by current state-of-the-art carbodiimide-based crosslinking. To mimic the constituents of natural bone extra cellular matrix (ECM), the crosslinked fibres were coated with carbonated hydroxyapatite (CHA) through biomimetic precipitation, resulting in an attractive biomaterial for guided bone regeneration (GBR), e.g. in bony defects of the maxillofacial region. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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