Catalyst free-click polymerization: A versatile method for the preparation of soybean oil based poly1,2,3-triazoles as coatings with efficient biocidal activity and excellent cytocompatibility

Click polymerization was applied for the preparation of soybean oil-based poly1,2,3-triazoles (PTAs). Azidated soybean oil (ASBO) was prepared and reacted with two different propyn-functional urethane monomers. Azidated derivatives of a quaternary pyridinium salt (APS) and Cloisite 30B (MMT-N-3) were also synthesized and tethered into the PTAs to control the physico-mechanical properties as well as biological activities. PTAs showed very good hardness (169-270 s(-1)) and adhesion strength (0.65 - 1.65 MPa) to Aluminum plate as model substrate. Qualitative and quantitative assessments confirmed promising cytocompatibility of PTAs against fibroblast cells (86-98% viability). Meanwhile, introduction of either APS or MMT-N3 in PTAs induced bactericidal and fungicidal activities against S. aureus, P. aeruginosa and C albicans. Higher biocidal activity (up to 99% reduction) was detected when these modifiers were used mutually in coatings materials. This work provides a new insight for utilizing a biorenewable material for the preparation of high-performance coatings suitable for biomedical applications. (C) 2015 Elsevier Ltd. All rights reserved.