Journal
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
Volume 105, Issue 491, Pages 1042-1055Publisher
AMER STATISTICAL ASSOC
DOI: 10.1198/jasa.2010.tm09129
Keywords
Acceleration; Correlation penalty; Empirical process; Mehler's identity; Nonnull z-values; Rms correlation
Categories
Funding
- NIH [8R01 EB002784]
- NSF [DMS0505673]
- Division Of Mathematical Sciences
- Direct For Mathematical & Physical Scien [0854973] Funding Source: National Science Foundation
Ask authors/readers for more resources
We consider large-scale studies in which there are hundreds or thousands of correlated cases to investigate, each represented by its own normal variate, typically a z-value. A familiar example is provided by a microarray experiment comparing healthy with sick subjects' expression levels for thousands of genes. This paper concerns the accuracy of summary statistics for the collection of normal variates, such as their empirical cdf or a false discovery rate statistic. It seems like we must estimate an N by N correlation matrix, N the number of cases, but our main result shows that this is not necessary: good accuracy approximations can be based on the root mean square correlation over all N . (N - 1)/2 pairs, a quantity often easily estimated. A second result shows that z-values closely follow normal distributions even under nonnull conditions, supporting application of the main theorem. Practical application of the theory is illustrated for a large leukemia microarray study.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available