Journal
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 24, Issue 8, Pages 1263-1273Publisher
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2012060596
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Funding
- National Heart, Lung, and Blood Institute [R01 HL35610, HL81744, HL72010, HL73219]
- Edna Mandel Foundation
- Foundation Leducq
- American Heart Association National Scientist Development Award [10SDG4280011]
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The renin-angiotensin-aldosterone system (RAAS) regulates BP and salt-volume homeostasis. Juxtaglomerular (JG) cells synthesize and release renin, which is the first and rate-limiting step in the RAAS. Intense pathologic stresses cause a dramatic increase in the number of renin-producing cells in the kidney, termed JG cell recruitment, but how this occurs is not fully understood. Here, we isolated renal CD44(+) mesenchymal stem cell (MSC)-like cells and found that they differentiated into JG-like renin-expressing cells both in vitro and in vivo. Sodium depletion and captopril led to activation and differentiation of these cells into renin-expressing cells in the adult kidney. In summary, CD44(+) MSC-like cells exist in the adult kidney and can differentiate into JG-like renin-producing cells under conditions that promote JG cell recruitment.
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