Journal
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 19, Issue 3, Pages 593-599Publisher
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2007030355
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Funding
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR024975] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL070938] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK045604, K24DK062849, P60DK020593] Funding Source: NIH RePORTER
- NCRR NIH HHS [UL1 RR024975] Funding Source: Medline
- NHLBI NIH HHS [R01 HL070938] Funding Source: Medline
- NIDDK NIH HHS [P30 DK020593, P60 DK020593, R01 DK045604, K24 DK062849, K24 DK62849, DK-20593, R01 DK45604] Funding Source: Medline
- NIEHS NIH HHS [P30 ES000267] Funding Source: Medline
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Adiposity contributes to inflammation and oxidative stress in the general population, but this association has not been examined in the chronic kidney disease (CKD) population. We investigated the relationship between body mass index, body fat percentage, and markers of inflammation (C-reactive protein) and oxidative stress (F-2-isoprostanes and protein thiols) in 184 patients with stages III to IV CKD and 43 healthy controls. We found that, on average, patients with CKD had 62% higher F2-isoprostanes, 7% lower protein thiols (a measure of enclogenous anti-oxidant capacity, inversely related to protein oxidation), and 150% higher C-reactive protein levels than healthy controls (all unadjusted P < 0.001). In separate multivariable linear regression models, body mass index and body fat percentage each positively correlated with levels of F-2-isoprostanes and C-reactive protein and negatively correlated with levels of protein thiols among patients with CKD after adjusting for age, sex, race, hypertension, diabetes mellitus, smoking history, estimated glomerular filtration rate, total cholesterol, serum albumin, and study site. We conclude that increased adiposity may amplify the oxidative stress and inflammation that accompany moderate to severe CKD. Interventions focused on weight loss may decrease the inflammatory ana oxidative burden in CKD, which may ultimately attenuate cardiovascular risk in this population.
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