Journal
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Volume 19, Issue 8, Pages 1444-1450Publisher
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2008010123
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Funding
- National Institutes of Health [AI064660, T32 5T32DK 007276-30]
- Roche Organ Transplantation Research Foundation
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Since the discovery of the Toll-like receptors and their crucial role as modulators of innate immunity, there has been increasing appreciation of their role in human health and disease. Toll-like receptor signaling is critical in defending against invading microorganisms, but sustained receptor activation is also implicated in the pathogenesis of inflammatory diseases. Here we review the role of Toll-like receptors and their endogenous ligands in various renal diseases, particularly their activation in the inflammatory response of ischemic kidney injury, organ transplantation, and immune-mediated glomerulonephritis.
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