Journal
JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
Volume 3, Issue 4, Pages 260-266Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jash.2009.03.003
Keywords
Diuretics; inflammation; RAAS inhibitors; sibships
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Funding
- National Institute of Health [U01 HL 54464, U01 HL 54457, U01 HL 54463, U01 HL 54481, R01 AR 30582]
- University of Mississippi Medical Center
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C-reactive protein (CRP) is a predictor of adverse cardiovascular outcomes. The effect of anti hypertensive therapy on CRP levels is largely unknown. We undertook a cross-sectional study of CRP levels among participants with primary hypertension on single-agent antihypertensive therapy in the community-based biracial Genetic Epidemiology Network of Arteriopathy cohort. Linear regression models were used to assess the association of anti hypertensive medication class with log-transformed CRP after adjustment for age, gender, ethnicity, body mass index, smoking, diabetes, hydroxymethylglutaryl CoA reductase inhibitor use, achieved blood pressure control (< 140/90 mm Hg), serum creatinine and urine albumin-to-creatinine ratios. There were 662 participants in the cohort taking single-agent therapy for hypertension. Median CRP levels differed across participants: 0.40 mg/dL for those on diuretics, 0.34 mg/dL on calcium-channel blockers, 0.25 mg/dL on beta-blockers and 0.27 mg/dL on renin-angiotensin-aldosterone system (RAAS) inhibitors (P<.001). With multivariable adjustment, the group on RAAS inhibitors had a 20% lower mean CRP on average than the group on diuretics (P=.044), differences between other medication classes were not apparent. Heart rate had a strong association with CRP (P<.001). Antihypertensive medication class may influence inflammation, particularly in patients on RAAS inhibitors. J Am Soc Hypertens 2009;3(4):260-266. (C) 2009 American Society of Hypertension. All rights reserved.
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