Journal
POLYHEDRON
Volume 99, Issue -, Pages 59-70Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2015.06.020
Keywords
Pyrazole and its derivatives; N-heterocyclic ligands; Antibacterial activity; Crystal structure; Spectra properties
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Funding
- National Natural Science Foundation of China [21071071, 21371086]
- Commonweal Foundation of Liaoning Province in China [2014003019]
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Molecular design and efficient synthetic procedures have been developed for pyrazole and its derivatives with different linkers. In particular, twelve compounds with -I or -NO2 substituted groups on the pyrazole ring were synthesized for the first time. These compounds are characterized by element analysis, IR, HNMR, M.P. and X-ray diffraction. In addition, some compounds and corresponding complexes were also assayed in vitro for their ability to inhibit the growth of representative Gram-positive bacteria, Gram-negative bacteria and the fungus. It was worthwhile to note that some compounds could be used as potential antibacterial agents. (C) 2015 Elsevier Ltd. All rights reserved.
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