Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 23, Issue 9, Pages 1512-1521Publisher
SPRINGER
DOI: 10.1007/s13361-012-0419-6
Keywords
Mass spectrometry; HDX; Software; H/D exchange; Protein dynamics; Automation
Funding
- US National Institutes of Health (NIH) National Institute of General Medical Sciences [R01-GM084041]
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Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for the interrogation of protein conformation and dynamics. While the data analysis challenge of HDX-MS has been addressed by a number of software packages, new computational tools are needed to keep pace with the improved methods and throughput of this technique. To address these needs, we report an integrated desktop program titled HDX Workbench, which facilitates automation, management, visualization, and statistical cross-comparison of large HDX data sets. Using the software, validated data analysis can be achieved at the rate of generation. The application is available at the project home page http://hdx.florida.scripps.edu.
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