Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 23, Issue 11, Pages 2043-2047Publisher
SPRINGER
DOI: 10.1007/s13361-012-0462-3
Keywords
Electrospray; Probe Electrospray; Pathology; Biological Specimen; Diagnostics
Funding
- Japan Science and Technology Agency (JST)
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We have examined several combinations of solvents with the aim of optimizing the ionization conditions for molecular diagnosis of malignant tumours by PESI-MS. Although the best conditions may depend on the actual species in the sample, the optimal conditions for renal cell carcinoma (RCC) were achieved by using alcohols. PESI-MS successfully delineated the differential expression of phospholipids (PCs) and triacylglycerols (TAGs) in noncancerous and RCC tissues by using these solvent systems. This study paves the way for the application of PESI-MS in medical samples.
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