Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 24, Issue 1, Pages 109-114Publisher
SPRINGER
DOI: 10.1007/s13361-012-0517-5
Keywords
Ion mobility spectrometry; Differential IMS; FAIMS; High-resolution analyses
Funding
- NIGMS [8P41 GM 103493-10]
- PNNL use-at-facility funds
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P41GM103493] Funding Source: NIH RePORTER
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As the resolution of analytical methods improves, further progress tends to be increasingly limited by instrumental parameter instabilities that were previously inconsequential. This is now the case with differential ion mobility spectrometry (FAIMS), where fluctuations of the voltages and gas pressure have become critical. A new high-definition generator for FAIMS compensation voltage reported here provides a stable and accurate output than can be scanned with negligible steps. This reduces the spectral drift and peak width, thus improving the resolving power (R) and resolution. The gain for multiply-charged peptides that have narrowest peaks is up to similar to 40 %, and R similar to 400-500 is achievable using He/N-2 or H-2/N-2 gas mixtures.
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