Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 22, Issue 4, Pages 607-611Publisher
SPRINGER
DOI: 10.1007/s13361-010-0072-x
Keywords
Electron capture dissociation; A radio-frequency-free electromagnetostatic cell
Funding
- NSF [CHE-0924027]
- Oregon Nanoscience and Microtechnologies Institute [09-31, 3.5]
- NIH (National Center For Research Resources) [R01RR026275]
- NIEHS (Environmental Health Sciences Center) [ES00210]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0924027] Funding Source: National Science Foundation
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Recently, we demonstrated that a radio-frequency-free electromagnetostatic (rf-free EMS) cell could be retrofitted into a triple quad mass spectrometer to allow electron-capture dissociation (ECD) without the aid of cooling gas or phase-specific electron injection into the cell (Voinov et al., Rapid Commun Mass Spectrom 22, 3087-3088, 2008; Voinov et al., Anal Chem 81, 1238-1243, 2009). Subsequently, we used our rf-free EMS cell in the same instrument platform to demonstrate ECD occurring in the same space and at the same time with collision-induced dissociation (CID) to produce golden pairs and even triplets from peptides (Voinov et al., Rapid Commun Mass Spectrom 23, 3028-3030, 2009). In this report, we demonstrate that ECD and CID product-ion mass spectra can be recorded at high resolution with flexible control of fragmentation processes using a newly designed cell installed in a hybrid Q-TOF tandem mass spectrometer.
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