Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 20, Issue 8, Pages 1391-1396Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jasms.2009.01.005
Keywords
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Funding
- European Commission's 7th Framework Programme [HEALTH-F4-2008-201648/ PROSPECTS]
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A new design of the Orbitrap (TM) mass analyzer is presented. Higher frequencies of ion oscillations and hence higher resolving power over fixed acquisition time are achieved by decreasing the gap between the inner and outer Orbitrap electrodes, thus providing higher field strength for a given voltage. Experimental results confirm maximum FWHM resolving power in excess of 350,000 at m/z 524 and 600,000 at m/ z 195, isotopic resolution of proteins above 40 kDa, and a single-shot dynamic range of 25,000. It was also found that mass shifts in the new design depend very little on space charge inside the analyzer. This performance was achieved using higher voltages and by careful balancing of construction tolerances and operation parameters, which appeared to vary in narrower ranges of timing than for a standard Orbitrap analyzer. (J Am Soc Mass Spectrom 2009, 20, 1391-1396) (C) 2009 Published by Elsevier Inc. on behalf of American Society for Mass Spectrometry
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