Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 19, Issue 4, Pages 598-608Publisher
SPRINGER
DOI: 10.1016/j.jasms.2008.01.004
Keywords
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In gas chromatography-mass spectrometry methods of analysis adopting the analyte's isotopic analog as the internal standard (IS), the cross-contribution (CC) phenomenon- contribution of IS to the intensities of the ions designating the analyte, and vice versa-has been demonstrated to affect the quantitation data. A novel approach based on the deviations of the empirically observed concentrations of a set of standards was developed to assess the accuracy of the empirically derived CC data. This approach demonstrated that normalization of ion intensities derived from the analyie and the IS generates reliable CC data. It further demonstrated that an ion-pair (designating the analyte and the IS) with similar to 5% or higher CC will result in a very limited linear calibration range.
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