Journal
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
Volume 18, Issue 4, Pages 354-357Publisher
OXFORD UNIV PRESS
DOI: 10.1136/amiajnl-2011-000245
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Funding
- National Institutes of Health [R01LM009725, R01LM009719, UL1RR024999, R01LM009520, U54HL108460, UL1RR031980, T15LM07442, UL1RR025014, P41LM007242, R01HG02288]
- Lucile Packard Foundation for Children's Health
- Hewlett Packard Foundation
- Komen Foundation
- Agency for Healthcare Research and Quality [R01HS019913]
- Institute for Genomic Medicine
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Nearly a decade since the completion of the first draft of the human genome, the biomedical community is positioned to usher in a new era of scientific inquiry that links fundamental biological insights with clinical knowledge. Accordingly, holistic approaches are needed to develop and assess hypotheses that incorporate genotypic, phenotypic, and environmental knowledge. This perspective presents translational bioinformatics as a discipline that builds on the successes of bioinformatics and health informatics for the study of complex diseases. The early successes of translational bioinformatics are indicative of the potential to achieve the promise of the Human Genome Project for gaining deeper insights to the genetic underpinnings of disease and progress toward the development of a new generation of therapies.
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