Journal
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Volume 59, Issue 1, Pages 96-100Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1532-5415.2010.03214.x
Keywords
hyperkyphosis; kyphosis; Timed Up and Go; mobility; aging
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Funding
- UCSF-Kaiser Building Interdisciplinary Research Careers in Women's Health
- National Institute of Child Health and Human Development
- Office of Research on Women's Health [5K12 HD052163]
- University of California at San Francisco (UCSF)
- Merck
- Roche
- Novartis
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K12HD052163] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000079] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR060828] Funding Source: NIH RePORTER
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OBJECTIVES To determine whether increasing kyphosis angle was independently associated with poorer mobility as measured according to the Timed Up and Go Test (TUG), after controlling for other established risk factors. DESIGN Prospective cohort study. SETTING Eleven clinical centers in the United States. PARTICIPANTS Two thousand seven hundred seventy-seven women aged 55 to 80 randomized to the placebo arms of the Fracture Intervention Trial, a randomized controlled trial of the effect of alendronate on risk for osteoporotic fractures. MEASUREMENTS The primary predictor was change in kyphosis angle, measured using the Debrunner Kyphometer; the outcome was change in mobility, measured as performance time on the TUG. Covariates were baseline age, kyphosis angle, body mass index (BMI), self-reported health status, grip strength, change in total hip bond mineral density (BMD), and number of vertebral fractures over a mean of 4.4 years. RESULTS Greater kyphosis angle predicted longer mobility performance times (P <.001), independent of other significant predictors of worsening mobility including age, baseline kyphosis, health status, grip strength, BMI, change in hip BMD, and new vertebral fractures. TUG performance times increased by 0.02 seconds (95% confidence interval (CI)=0.01-0.03) for every 5 degrees increase in kyphosis angle, more than the increase in mobility time of 0.01 seconds (95% CI=0.005-0.03) over 1 year observed in this cohort. CONCLUSION Increasing kyphosis angle is independently associated with worsening mobility. Interventions are needed to prevent or reduce increasing kyphosis and mobility decline.
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